Publications
Independent Career
*Denotes Equal Contribution, #Denotes Undergraduate Author
Fluorescein Diacetate (FDA) Should Not Be Used to Study Human Carboxylesterase 2 (CES2) in Complex Biological Systems Without Validation
Fluorescein Diacetate (FDA) Should Not Be Used to Study Human Carboxylesterase 2 (CES2) in Complex Biological Systems Without Validation
- Karns, C. J.; Singh, A.; Walk, M. R.#; Adusah, E.; Pearson, A. M.#; Knebel, S. J.; Beck, M. W. Bioorg. Med. Chem. Lett. 2025, 128, 130331.
- Preprint version available at ChemRxiv
- Part of Special Issue in Honor of Professor Bryan Dickinson for 2025 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry
- All data from publication is publicly available at OSF.io
Fluorogenic Chemical Tools to Shed Light on CES1-Mediated Adverse Drug Interactions
- Karns, C. J.; Spidle, T. P.#*; Adusah, E.*; Nehls, J. E.; Gao, M.#; Beck, M. W. Chem. Commun. 2024, 60, 12369.
- Featured on Back Cover
- Featured in the themed collection: 2024 Emerging Investigators
- All data from publication is publicly available at OSF.io
Carbonate-Based Fluorescent Chemical Tool for Uncovering Carboxylesterase 1 (CES1) Activity Variations in Live Cells
- Singh, A.; Gao, M.#; Karns, C. J.#; Spidle, T. P.#; Beck, M. W. ChemBioChem 2022, 23 , e202200069.
- Featured on Front Cover
Human Carboxylesterases and Fluorescent Probes to Image Their Activity in Live Cells
- Singh, A.; Gao, M.#; Beck, M. W. RSC Med. Chem. 2021, 12, 1142.
- Featured in the themed collection: Emerging Investigators
Publications and Patents from Undergraduate, Ph.D., and Postdoctoral Studies
*Denotes Equal Contribution, #Denotes Undergraduate Author
New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity Against Breast Cancer Cells
Development of a Split Esterase for Protein–Protein Interaction-Dependent Small-Molecule Activation
Synthetic Substrates for Enzymes That Catalyze Reactions of Modified Cysteines and Related Methods
A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells
Minor Structural Variations of Small Molecules Tune Regulatory Activities Toward Pathological Factors in Alzheimer's Disease
Michael Addition-Based Probes for Ratiometric Fluorescence Imaging of Protein S-Depalmitoylases in Live Cells and Tissues
Structure-Mechanism-Based Engineering of Chemical Regulators Targeting Distinct Pathological Factors in Alzheimer’s Disease
A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer’s Disease
Chapter 10: Ligand Design to Target and Modulate Metal-Protein Interactions in Neurodegenerative Diseases
Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications
Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-β Species
New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity Against Breast Cancer Cells
- Lisic, E. C.; Grossarth, S. N.#; Bowman, S. B.; Hill, J. L.#; Beck, M. W.#; Deweese, J. E.; Jiang, X. H. Open J. Med. Chem. 2022, 12, 1.
Development of a Split Esterase for Protein–Protein Interaction-Dependent Small-Molecule Activation
- Jones, K., A.; Kentala, K.; Beck, M. W.; An, W.; Lippert, A. R.; Lewis, J. C.; Dickinson, B. C. ACS Cent. Sci. 2019, 5, 1768.
- Featured in ACS Cent. Sci. 2019, 5, 1744.
- Preprint version available at ChemRxiv
Synthetic Substrates for Enzymes That Catalyze Reactions of Modified Cysteines and Related Methods
- Dickinson, B.C.; Kathayat, R.S.; Beck, M.W. U.S. Patent 10,413,583, September 17, 2019.
A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells
- Qiu, T.*; Kathayat, R. S.*; Cao, Y.*; Beck, M. W.; Dickinson, B. C. Biochemistry 2018, 57, 221.
Minor Structural Variations of Small Molecules Tune Regulatory Activities Toward Pathological Factors in Alzheimer's Disease
- Beck, M. W.; Derrick, J.S.; Suh, J.-M.; Kim, M.; Korshavn, K. J.; Kerr, R. A.; Cho, W. J.; Larsen, S. D.; Ruotolo, B. T.; Ramamoorthy, A.; Lim, M. H. ChemMedChem 2017, 12, 1828.
- Featured on Front Cover
Michael Addition-Based Probes for Ratiometric Fluorescence Imaging of Protein S-Depalmitoylases in Live Cells and Tissues
- Beck, M. W.; Kathayat, R. S; Cham, C. M.; Chang, E. B.; Dickinson, B. C. Chem. Sci. 2017, 8, 7588.
Structure-Mechanism-Based Engineering of Chemical Regulators Targeting Distinct Pathological Factors in Alzheimer’s Disease
- Beck, M. W.*; Derrick, J. S.*; Kerr, R. A.; Oh, S. B.; Cho, W. J.; Lee, S. J. C.; Ji, Y.; Han, J.#; Tehrani, Z. A.; Suh, N.; Kim, S.; Larsen, S. D.; Kim, K. S.; Lee, J.-Y.; Ruotolo, B. T.; Lim, M. H. Nature Commun. 2016, 7, 13115.
A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer’s Disease
- Beck, M. W.*; Oh, S. B.*; Kerr, R. A.; Lee, H. J.; Kim, S. H.; Kim, S.; Jang, M.; Ruotolo, B. T.; Lee, J.-Y.; Lim, M. H. Chem. Sci., 2015, 6, 1879.
- Recommended as "Very Good" on Faculty of 1000.
Chapter 10: Ligand Design to Target and Modulate Metal-Protein Interactions in Neurodegenerative Diseases
- Beck, M. W.; Pithadia, A. S.; DeToma, A. S.; Korshavn, K. J.; Lim, M. H. In Ligand Design in Medicinal Inorganic Chemistry John Wiley & Sons: Chichester, West Sussex, 2014, pp 256-286.
- Featured in Angew. Chem. Int. Ed., 2015, 54, 2324.
Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications
- Liu, Y.*#; Kochi, A.*; Pithadia, A. S.; Lee, S.; Nam, Y.; Beck, M. W.; He, X.; Lee, D.; Lim, M. H. Inorg. Chem., 2013, 52, 8121.
Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-β Species
- Pithadia, A. S.*; Kochi, A.*; Soper, M. T.; Beck, M. W.; Liu, Y.; Lee, S.; DeToma, A. S.; Ruotolo, B. T.; Lim, M. H. Inorg. Chem. 2012, 51, 12959.